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The average number of voidings and mean voiding volumes revealed significant improvement after the 12 weeks' treatment period, with a significant reduction and increase, respectively. Mean voiding volume increased from ml to , which apparently was not reflected in a corresponding reduction of number of daily voids from 15,5 to VAS values decreased from 5,4 to 3,6 pain and from 6,0 to 3,5 urgency after the treatment cycle, showing a significant improvement.

METHODS Women from 18 to 49 years of age with symptoms of cystitis provided specimens of midstream urine, after which we collected urine by means of a urethral catheter for culture catheter urine. We compared microbial species and colony counts in the paired specimens. The primary outcome was a comparison of positive predictive values and negative predictive values of organisms grown in midstream urine, with the presence or absence of the organism in catheter urine used as the reference.

RESULTS The analysis of episodes of cystitis in women yielded paired specimens of midstream urine and catheter urine that could be evaluated. Among 41 episodes in which enterococcus, group B streptococci, or both were found in midstream urine, E. Funded by the National Institute of. Hemorrhagic cystitis : A challenge to the urologist. Severe hemorrhagic cystitis often arises from anticancer chemotherapy or radiotherapy for pelvic malignancies. Infectious etiologies are less common causes except in immunocompromised hosts.

These cases can be challenging problems for the urologist and a source of substantial morbidity and sometimes mortality for the patients. A variety of modalities of treatment have been described for the management of hemorrhagic cystitis but there is none that is uniformly effective.

Some progress has been made in the understanding and management of viral hemorrhagic cystitis. This article reviews the common causes of severe hemorrhagic cystitis and the currently available management options. Objectives To investigate whether polyomaviruses contribute to interstitial cystitis pathogenesis. Subjects and Methods A prospective study was performed with 50 interstitial cystitis cases compared with 50 age-matched, disease-free controls for the frequency of polyomaviruria.

Associations between polyomaviruria and disease characteristics were analysed in cases. Polyomavirus in urine and bladder tissue was detected with species JC virus vs. BK virus specific, real-time PCR. There was a significant increase in the frequency of polyomavirus shedding between cases and controls p cystitis cases after adjustment for age and sex OR 6.

There was a significant association among cases between the presence of BK viruria and response to intravesical Clorpactin therapy OR 4. Conclusion The presence of polyomaviruria was found to be associated with the ulcerative form of interstitial cystitis.

Clorpactin, which has anti-DNA virus activity, was more likely to improve symptoms in the presence of BK viruria. These data from this pilot study suggest associations between polyomaviruria and interstitial cystitis warranting further investigation. Cystitis glandularis in a cat. An 8-year-old intact male Persian cat was presented for investigation of chronic haematuria. The cat had episodes of haematuria on several occasions that were non-responsive to antimicrobial therapy.

Abdominal ultrasound examination revealed dilation of the renal pelvis and ureters of both kidneys. The urinary bladder wall was thickened, a mass of heterogeneous echogenicity filled the lumen of the bladder, and two parallel thin hyperechoic lines were identified within the lumen, which suggested a urethral catheter.

Differential diagnoses for the urinary bladder mass included cystitis and neoplasia. The mass was surgically removed from the urinary bladder, and a urethral catheter was found embedded in the mass. Histopathological findings were consistent with cystitis glandularis of a typical type. Periodic bladder ultrasonographic studies were performed; at the time of writing, over 2 years later, recurrence had not been detected.

Long-term results of amitriptyline treatment for interstitial cystitis. We performed a prospective, open label study to examine the safety and efficacy of the long-term administration of the tricyclic antidepressant amitriptyline in patients with interstitial cystitis IC. Amitriptyline was received strictly at bedtime following an established self-titration protocol without a limitation of the maximum daily dose. Patients reporting improvement in a global response assessment questionnaire were considered treatment responders.

Further efficacy measures were changes in pain and urgency, functional bladder capacity and frequency. Changes in the O'Leary-Sant IC index and rating of overall satisfaction with the therapeutic outcome were also reported. The overall mean dose was 55 mg range Improvement in the various IC symptoms was statistically significant compared with baseline.

Long-term administration of amitriptyline is a feasible, safe and effective treatment for IC, provided that the drug is used judiciously to minimize adverse effects. The therapeutic response to amitriptyline was uniformly observed in patients fulfilling NIDDK criteria and in those with the pure clinical diagnosis of IC.

Case-control study of medical comorbidities in women with interstitial cystitis. We used physician assigned diagnoses in an electronic medical record to assess comorbidities associated with interstitial cystitis. A computer search of the administrative database at Kaiser Permanente Northwest, Portland, Oregon was performed for May 1, to April 30, All women with a medical record diagnosis of interstitial cystitis ICD-9 code These cases were then matched with 3 controls each based on age and duration in the health plan.

The medical diagnoses using ICD-9 codes restricted to 3 digits assigned to these 2 groups were compared using the OR. A total of cases and matched controls were analyzed. There were 23 diagnoses that were significantly more common in cases than in controls p symptoms. Additional specific conditions associated with interstitial cystitis were gastritis OR A diagnosis of interstitial cystitis was associated with multiple other unexplained physical symptoms and certain psychiatric conditions.

Studies to explore the possible biological explanations for these associations are needed. Eosinophilic cystitis with recurrent urinary retention: case report. Eosinophilic cystitis is a rare inflammatory disease of the bladder whose origin, pathogenesis, and treatment are unknown.

Frequency, dysuria, and hematuria are frequent symptoms. Here, we report a rare occurrence of recurrent urinary retention and repetitive catheterization. A year-old male presented with acute urinary retention and intermittent gross hematuria of 2 weeks duration. Urethral catheterization followed by a trial without catheter, was successful. Complete blood count showed presence of eosinophils eosinophilia and computed tomography of kidneys, ureter and bladder with contrast showed thickened bladder wall and small prostate.

Cystoscopy revealed an erythematous lesion over the anterior wall. The rest of the mucosa was normal. Transurethral biopsies of the lesion were performed and histologic examination showed features of eosinophilic cystitis. Despite multiple medication regimens containing corticosteroids and antihistamines, he presented with recurrent urinary retention, approximately once every month.

After 6 months, he was started on bethanechol, which led to no catheterization for up to 2 years. To the best of our knowledge, this is the first report on the successful use of bethanechol as a treatment for eosinophilic cystitis with recurrent urinary retention. The Interstitial Cystitis IC has been considered in the past an uncommon pathology, however it has received a special attention during the last 20 years, scientific articles published since to There are many therapeutic options not at all satisfactory because there isn't consensus about diagnostic and treatment.

To share our experiences in the treatment of interstitial cystitis , additionally, to comment on the therapeutic response of treatment used. The diagnosis was done in agreement with the concepts of Interstitial Cystitis group from clinical and cystoscopic characteristics. Fuermaier, Anselm B. A bladder infection can be painful and annoying, Nighttime bed-wetting on its own isn' Incidence and clinical characteristics of interstitial cystitis in the community.

We utilized physician-coded diagnoses and chart reviews to estimate the incidence of interstitial cystitis IC in women. Chart reviews were performed and patient demographics, diagnosing physicians, and symptom characteristics were recorded. The IC incidence rate was 15 per , women per year. The mean age of the patients was 51 years range years.

Cases diagnosed by primary care physicians had a shorter median symptom duration 9 months compared with those diagnosed by urologists 1 year and gynecologists 3 years. IC is an uncommon diagnosis in the community setting, with an incidence rate of 15 per , women per year. Data were analyzed with univariate methods or multivariate logistic regression analysis accordingly.

Mean age and duration of symptoms was A longer. Differences in initial symptom scores between myogenous TMD patients with high and low temporomandibular opening index. The temporomandibular opening index TOI is a more useful measure of mandibular movement than linear mouth opening, since it is independent of age, gender, ramus length, and gonial angle.

It is also useful when categorizing temporomandibular disorder TMD patients into diagnostic groups. Two subgroups of myogenous patients have been identified, one with a high and one with a low temporomandibular opening index. This study examined initial symptom severity in these two subgroups. Thirty-three 33 patients with a myogenous temporomandibular disorder were recruited. Twenty-six 26 were female and seven male. Eleven were found to be in the high temporomandibular opening index group and the remaining 22 in the low group.

Symptom severity scores were determined prior to the start of treatment. Pain, joint sounds, headache, and neck pain were all rated by patients on a four-point verbal response scale. These symptom scores were compared between the two subgroups using the Wilcoxon two sample test. TMD patients with high temporomandibular opening index appeared to have more severe signs and symptoms of TMD than patients with a low index.

The project is ongoing. Using population based screening methods, we applied these case definitions to determine the prevalence of these conditions in men. An initial men screened positive, of whom met the inclusionary criteria and completed the telephone interview.

These case definitions were used to classify subjects into groups based on diagnosis. Differences in the other primary symptoms associated with these conditions probably influence how urgency is perceived. There is a need for a brief symptom index for advanced kidney cancer that includes perspectives of both patients and clinicians and is consistent with the Food and Drug Administration's guidance for patient-reported outcome measures.

Fifty patients with advanced kidney cancer provided open-ended and survey responses ranking their most important symptoms. Responses were reconciled with published clinician reports of the most important symptoms. Ten experienced oncologists rated symptoms as disease- or treatment-related.

Patients completed quality-of-life and performance status measures. A item index was produced from symptoms that were rated as most important by patients or clinicians. Preliminary evidence suggests that the total score and DRS and FWB subscales are reliable and valid as summary indexes. The TSE subscale may be least relevant given the advent of newer therapies. Depressive symptoms mediate the association between fear of crime and higher body mass index.

To investigate pathways in the association between fear of crime and obesity. A cross-sectional survey was administered among residents aged 18 years and older across all Census tracts. Genesee County, Michigan. A total of residents. Body mass index BMI was calculated by using the respondents' reported height and weight. Composite fear-of-crime and depressive symptoms scores were calculated by using several survey items.

Path analysis examined the effects of fear of crime on BMI. Fear of crime was associated with higher BMI. Depressive symptoms mediated the relationship between fear of crime and BMI p symptoms and BMI p symptoms , which in turn were associated with reduced exercise and subsequently higher BMI. Correlation between vocal tract symptoms and modern singing handicap index in church gospel singers.

To verify the correlation between vocal tract discomfort symptoms and perceived voice handicaps in gospel singers, analyzing possible differences according to gender. All participants answered two questionnaires: Vocal Tract Discomfort VTD scale and the Modern Singing Handicap Index MSHI that investigates the vocal handicap perceived by singers, linking the results of both instruments p symptoms , the higher the vocal handicap for singing.

Female gospel singers present higher frequency and intensity of vocal tract discomfort symptoms , as well as higher voice handicap for singing than male gospel singers. The higher the frequency and intensity of the laryngeal symptoms , the higher the vocal handicap will be. Fluorescein angiography of the bladder: technique and relevance to bladder cancer and interstitial cystitis patients.

Fluorescein angiography has been used in the study of bleeding vessels, neovascularity, tumors and ischemic tissues in a variety of disorders. This pilot study was designed to evaluate the feasibility, safety and relevance of this interesting technology for the evaluation of bladder wall vessels in patients with interstitial cystitis and bladder cancer.

Five patients with National Institutes of Health defined interstitial cystitis symptoms and 10 with bladder cancer were studied during cytoscopy while they were under general anesthesia. A yellow-green barrier filter nm. Patients received a 5 ml. After hydrodistension, glomerulations in interstitial cystitis patients were more prominent with fluorescein angiography and occurred in the venule phase.

Areas of papillary transitional cell tumor and carcinoma in situ developed a brilliant yellow-green fluorescence. Adjacent normal urothelium was nonfluorescent and provided a contrasting dark background facilitating the detection of all lesions. No allergic reaction or other adverse effect related to the fluorescein injection was observed.

These unique observations in a limited number of patients suggest that fluorescein angiography of the bladder is a safe and simple procedure. This preliminary report underscores the relevance of fluorescein angiography in the detection of bladder tumor and offers a new approach to the evaluation of bladder wall vessels in interstitial cystitis patients.

Anxiety Sensitivity Index ASI-3 subscales predict unique variance in anxiety and depressive symptoms. Anxiety sensitivity AS has been implicated in the development and maintenance of a range of mental health problems. The development of the Anxiety Sensitivity Index - 3, a psychometrically sound index of AS, has provided the opportunity to better understand how the lower-order factors of AS - physical, psychological, and social concerns - are associated with unique forms of psychopathology.

The present study investigated these associations among 85 treatment-seeking adults with high AS. Participants completed measures of AS, anxiety, and depression. Multiple regression analyses controlling for other emotional disorder symptoms revealed unique associations between AS subscales and certain types of psychopathology.

Only physical concerns predicted unique variance in panic, only cognitive concerns predicted unique variance in depressive symptoms , and social anxiety was predicted by only social concerns. Findings emphasize the importance of considering the multidimensional nature of AS in understanding its role in anxiety and depression and their treatment. Associations between depressive symptoms , self-efficacy, eating styles, exercise and body mass index in women.

This article explores cross-sectional associations between depressive symptoms and body mass index BMI in women working in schools in the Greater New Orleans area. Self-efficacy for eating and exercise, eating styles, and exercise are examined as potential pathways. This is a secondary data analysis of women who were participating in a workplace wellness randomized controlled trial to address environmental factors influencing eating and exercise behaviors using baseline data prior to the intervention.

BMI was the primary outcome examined. Path analysis suggested that increased depressive symptoms were associated with increased BMI in women. Indirect effects of depressive symptoms on BMI were found for increased healthy eating self-efficacy, increased emotional eating, and decreased exercise self-efficacy.

The association between greater healthy eating self efficacy and BMI was unexpected, and may indicate a suppressor effect of eating self-efficacy in the relationship between depressive symptoms and BMI in women. The findings suggest the importance of depressive symptoms to BMI in women. Targets for interventions to reduce BMI include targeting depressive symptoms and related sequelae including self-efficacy for exercise, and emotional eating.

Further investigation of eating self-efficacy and BMI are recommended with particular attention to both efficacy for health eating and avoidance of unhealthy foods. Forty-two patients with more than 2 episodes of cystitis in the proceeding 6 months were treated for 3 months with one capsule daily of ECE and observed for a further 6 months. The primary efficacy criterion was the number of episodes of recurrent cystitis during the 6 months after treatment compared to those during the 6 months before treatment.

At the end of the 9-month trial, 34 patients all women were eligible for statistical analysis. Their mean age was The number of recurrences was significantly lower during the 6-month follow-up period than during the 6 months preceding the trial 0. There were no serious adverse events related to the study drug.

Our study demonstrates the efficacy and safety of ECE in the prophylactic treatment of chronically recurrent cystitis. Distribution of mast cell subtypes in interstitial cystitis : implications for novel diagnostic and therapeutic strategies?

To identify the presence and geographical distribution of mast cell MC subtypes: MC T tryptase positive-chymase negative and MC TC tryptase positive-chymase positive in bladder tissue. Stained sections were photographed, and positively stained MCs were quantified using ImageJ.

Data were analysed using descriptive statistics and individual paired t-tests. There was a significant difference in the density of MCs between each layer of the disease bladder, with the greatest accumulation within the detrusor p cystitis. Our results suggest that mastocytosis is present within all layers of disease bladder, especially the muscle layer.

A high influx of MC TC in the mucosa of individuals who also had ulceration noted within their diagnostic notes may be of the Hunner's ulcer subclassification. No commercial use is permitted unless otherwise expressly granted. Clemens, J. Quentin; Clauw, Daniel J. However, no studies have directly compared the characteristics of these syndromes in men and women. However, a substantial proportion of men also report these types of bladder symptoms.

A total of 17 studies enrolling patients were identified. Pooled analyses demonstrated that SNM was associated with great reduction in pelvic pain weighted mean difference [WMD] The management of interstitial cystitis IC is predominantly the reduction of the symptoms of frequency, urgency, and pain. Multimodal treatment approaches for IC are helpful in customizing therapy for individual patients.

Complementary and alternative therapies are a quintessential addition to the therapeutic armamentarium and frequently include dietary modification, nutraceuticals, bladder training, neuromodulation, stress reduction, and sex therapy.

Dietary modification involves elimination of bladder irritants, fluid regulation, and a bowel regimen. Nutraceuticals studied for the treatment of IC include calcium glycerophosphate, L-arginine, mucopolysaccharides, bioflavinoids, and Chinese herbs. Bladder training is effective after pain reduction.

The neuromodulation of high-tone pelvic-floor muscle dysfunction is achieved with physical therapy and acupuncture. Stress reduction and sex therapy are best administered by a qualified stress manager and sex therapist. Multimodal, nonconventional management may add efficacy to the treatment of IC.

Performance of the American Urological Association Symptom Index with and without an additional urge incontinence item. We correlated the items and scales and examined whether adding the UI question resulted in better prediction of disease-specific health status. Eighteen women with advanced ovarian cancer completed the NFOSI and participated in cognitive interviews to assess: a the understandability of the NFOSI; and b the things patients have in mind when responding to the item, "I am bothered by side effects of treatment;" and c the interpretation patients place on items relating to fatigue and lack of energy.

Interviews were recorded and transcribed for qualitative analysis. When responding to the item, "I am bothered by side effects of treatment," fatigue, nausea, and neuropathy constituted the most frequently mentioned concerns. Among the participants who were asked, eight participants responded that "fatigue" and "lack of energy" were the same concept and nine responded they were different. Participants associated "fatigue" with tiredness and associated "lack of energy" with the inability to perform daily tasks and activities.

Item revisions, deletions or additions do not appear warranted. Recurrent uncomplicated cystitis in women: allowing patients to self-initiate antibiotic therapy. Acute uncomplicated cystitis is a lower urinary tract infection occurring in the absence of anatomic or functional abnormalities of the urinary tract or any other complicating factors. The organism responsible is often an enterobacterium, especially Escherichia coli. What is the role of antibiotic therapy for non-pregnant women with recurrent acute uncomplicated cystitis?

We reviewed the available evidence using the standard Prescrire methodology. A single oral dose of fosfomycin trometamol is the antibiotic of choice for treating an episode of acute uncomplicated cystitis. Alternative antibiotics are certain fluoroquinolones or co-trimoxazole a fixed-dose combination of sulfamethoxazole and trimethoprim.

For recurrent acute uncomplicated cystitis , cranberry juice has modest efficacy in reducing the frequency of episodes. A number of non-drug measures are typically proposed, although their effects are unproven: drinking sufficient fluids and urinating regularly; urinating after sexual intercourse; and avoiding spermicides.

The strategy that results in the lowest antibiotic exposure is a short course of antibiotics for each episode of urinary tract infection, initiated as soon as clinical symptoms appear. Long-term antibiotic therapy is sometimes offered. According to one systematic review, women taking long-term prophylactic antibiotic therapy had about 6 times fewer clinical recurrences than with placebo. According to one randomised trial, 3 g of fosfomycin trometamol taken as a single dose every ten days reduced the frequency of recurrence, resulting in 0.

When cystitis appears to be associated with sexual intercourse, two small randomised trials suggest that routine postcoital antibiotic treatment is more effective. Gastroesophageal reflux may contribute to the development of cricopharyngeal dysfunction and Zenker's diverticulum. Common dictum suggests that if upper esophageal sphincter tone is reduced through cricopharyngeal myotomy, symptoms of laryngopharyngeal reflux may worsen. We hypothesized that patients who undergo myotomy should show decreased dysphagia symptoms with concurrent worsening of reflux symptomatology and that these changes would be greater in those patients undergoing complete versus partial myotomy.

A retrospective chart review was performed for patients who underwent endoscopic or open cricopharyngeal myotomy, with or without Zenker's diverticulectomy. Patients who underwent partial myotomy via endoscopic stapling of Zenker's diverticulum were compared with patients who underwent complete myotomy either endoscopic laser-assisted or via an open transcervical approach. The patients were further subdivided into three groups for data analysis: endoscopic staple diverticulotomy, laser cricopharyngeal myotomy, and open approach.

A total of 41 patient charts were reviewed. Of these 41 patients, 17 underwent endoscopic stapler-assisted diverticulotomy, 4 underwent endosopic laser-assisted cricopharyngeal myotomy, and 20 underwent open transcervical cricopharyngeal myotomy, with diverticulectomy as indicated. Mean pre- and postoperative RSIs were Concern for worsening of reflux symptoms following surgery does not appear to be clinically common. Published by. Background Overweight and obese individuals are at increased risk for gastroesophageal reflux disease GERD.

We observed a dose-dependent relationship between increasing BMI and frequent reflux symptoms multivariate P for trend symptoms OR 2. Our findings suggest that even modest weight gain among normal weight individuals may cause or exacerbate reflux symptoms. This study examined the association between body mass index BMI changes over time and the risk of elevated depressive symptoms in a cohort of Midwestern rural adults. The longitudinal study used data from a telephone survey in including 1, men and women enrolled in the Walk the Ozarks to Wellness Project from 12 rural communities in Missouri, Arkansas, and Tennessee.

For each unit increase in BMI over time, representing an average increase of about 5. Our findings hold important public health implications given the increasing rates of overweight and obesity over the past couple of decades, particularly among rural adults. BK virus-associated hemorrhagic cystitis in a pediatric lung transplant recipient. BKV was first postulated to be a potential pathogen in when it was isolated in the urine of a renal transplant recipient.

The pathology of BKV is generally confined to the urinary tract. In renal transplant recipients, BKV has been associated with hemorrhagic cystitis , urethral stenosis, and interstitial nephritis. Reports of BKV infection in lung transplant recipients are limited to a few case reports in adult patients. To our knowledge, there are no published reports of pediatric lung transplant recipients with BKV-associated hematuria.

We hereby report a case of BKV-induced hemorrhagic cystitis in a pediatric lung transplant recipient. Koufman proposed the term to designate Laryngeal Pharyngeal Reflux LPR symptoms , signs or tissue damage resulting from aggression of the gastrointestinal contents in the upper aerodigestive tract. Belafsky et al proposed a score that points to inflammatory laryngeal signs through videolaryngoscopic findings, the Reflux Finding Score RFS.

The objective of this study is to provide a comparison between the Reflux Finding Score and the Reflux Symptom Index in the practice of Otorhinolaryngology. We excluded nine patients and the study group was patients. The study group consisted of patients 88 women and 38 men. Their main complaints were cough The RSI ranges from 13 to 42 with a mean of The RFS ranged from 3 to 19 with a mean of 9.

Based on the clinical index , the specialist can evaluate the need for further tests. Ultrasonography in the diagnosis of hemorrhagic cystitis — a complication of bone marrow transplantation in pediatric oncology patients. Objective The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children. Material and methods The study involved an analysis of clinical material and the results of imaging tests performed in patients who underwent hematopoietic cell transplantation.

Ultrasonographic findings in 42 patients with hemorrhagic cystitis were analyzed in detail. The ultrasound images served to assess the severity of hemorrhagic cystitis and the results were compared with the clinical assessment of the disease on the Droller scale, as well as the laboratory and endoscopic tests. Results In the studied group of patients hemorrhagic cystitis following allogeneic transplantation was diagnosed in The study revealed a higher incidence of hemorrhagic cystitis in children above 10 years of age.

Grade 3 according to the Droller was diagnosed in The number of ultrasound examinations depended on the clinical symptoms , severity, duration and co-occurrence of other complications following the transplantation and was within the 1—15 range average: 4. Grades 3 and 4 were related to the poor clinical condition of the patients and to their longer hospitalization.

During this period there was an increased risk of renal malfunction and acute renal failure, post-inflammatory narrowing of the ureters, hydronephrosis, and in grade 4 the fibrosis of the bladder with reduced bladder capacity. Analyses demonstrated a significant correlation between the ultrasound image of the bladder wall and the clinical severity. Conclusions Ultrasound with Doppler options remains the primary diagnostic tool in the evaluation of hemorrhagic cystitis , and is useful in terms of its diagnosis, determination of the severity, and.

The objective of the present study was to evaluate the effectiveness of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract NDM , when associated to antibiotic therapy, in reducing the persistence of recurrent cystitis in this risk population.

Patients and Methods: Sixty breast cancer survived women with recurrent cystitis were retrospectively examined. Group 1, comprised of 40 patients treated with antibiotic therapy associated with NDM lasting for six months, Group 2 comprised of 20 patients treated with antibiotics alone.

Results: The use of NDM in combination with antibiotic therapy showed a significant reduction in positive urine cultures, compared to antibiotics alone. Subjects of Group 1 rather than those of Group 2, showed improvement in symptoms score of urgency, frequency, urge incontinence, recurrent cystitis , bladder and urethral pain. Conclusion: In breast cancer survived women affected by genitourinary discomfort, the combination of NDM and antibiotic therapy showed a greater efficacy in reducing urinary tract infections and urinary discomfort with respect to antibiotic use only.

Breast cancer survivors in adjuvant therapy, frequently experience the estrogen deficiency with genitourinary symptoms mostly represented by recurrent bacterial cystitis. Sixty breast cancer survived women with recurrent cystitis were retrospectively examined.

The use of NDM in combination with antibiotic therapy showed a significant reduction in positive urine cultures, compared to antibiotics alone. In breast cancer survived women affected by genitourinary discomfort, the combination of NDM and antibiotic therapy showed a greater efficacy in reducing urinary tract infections and urinary discomfort with respect to antibiotic use only.

George J. Delinasios , All rights reserved. The bladder pain syndrome BPS is a spectrum of urological symptoms characterised by bladder pain with typical cystoscopic features. Diagnosis and management of this syndrome may be difficult. There is no evidence-based management approach for the diagnosis or treatment of BPS. The objective of this study was to critically review and summarise the evidence relating to the diagnosis and treatment of the bladder pain syndrome.

A review of published data on the diagnosis and treatment of the BPS was performed. Our search was limited to English-language articles, on the "diagnosis", and "management" or "treatment" of "interstitial cystitis " and the "bladder pain syndrome" in "humans. All urodynamic volumes are reduced in patients with BPS. Associated conditions include psychological distress, depression, history of sexual assault, irritable bowel syndrome and fibromyalgia. Cystoscopy remains the test for definitive diagnosis, with visualisation of haemorrhage on cystoreduction.

A multidisciplinary treatment approach is essential in the management of this condition. Orally administered amitriptyline is an efficacious medical treatment for BPS. Sacral or pudendal neuromodulation is effective, minimally invasive and safe. Surgery is reserved for refractory cases. There remains a paucity of evidence for the diagnosis and treatment of BPS. We encountered significant heterogeneity in the assessment of symptoms , duration of treatment and follow up of patients in our literature review.

Chart reviews and telephone surveys were then conducted to determine their posttherapy course. Of 68 eligible women, 55 Their mean age at therapy onset was At the end of the follow-up period, 19 of the 55 women Univariate and multivariate analyses showed that DMSO treatment failure was more likely in patients with pretreatment day-time urinary frequency more than 15 episodes per day OR 1.

Prevention of Cystitis : Travelling between the Imaginary and Reality. As a preventive strategy, increased water intake is often recommended to women affected by recurrent cystitis ; however, clinical data are sparse and conflicting. This review evaluates the preventive approaches used as alternatives to obtain relief from the burden of cystitis and focuses on the effect of fluid intake on urinary tract infection. Karger AG, Basel. Risk factors for recurrent cystitis following acute cystitis in female patients.

We conducted a retrospective analysis of acute cystitis AC patients to evaluate the risk factors of recurrent cystitis RC patients following AC. The clinical records of subjects with a confirmed diagnosis of AC and 90 healthy subjects who visited the Health Promotion Center between and were reviewed. A patient was diagnosed with RC if she was treated for three or more symptomatic episodes of cystitis over a month period. To examine the association between body mass index BMI and symptom severity and quality of life QOL in patients with fibromyalgia.

Intravesical instillations were performed weekly in first month, every 15 days in the second month and monthly in third and fourth months, for a total of 8 doses. All patients had a potassium sensitivity test PST initially. Wilcoxon and Mann-Whitney U tests were used for statistical analysis. In total, 53 patients met the study criteria.

There were 30 patients in the HA-CS group mean age: The initial PST was positive in Eight patients had mild adverse events. An important limitation of our study is that the HA dosage of the 2 treatment arms were different. It would be more appropriate with same HA dosage in both groups; however, there was no commercially available glycosaminoglycan GAG substance with same HA dosage for single and combination therapy.

Large, long-term randomized studies. Further evidence for a broader concept of somatization disorder using the somatic symptom index. Both groups showed a qualitatively similar pattern of psychopathological comorbidity and had elevated scores on measures of depression, hypochondriasis, and anxiety. A good discrimination between mild and severe forms of somatization was found by using the SSI criterion.

The results provide further evidence for the validity of the SSI concept, which reflects the clinical relevance of somatization in addition to the narrow definition of somatization disorder. Decreased physical activity attributable to higher body mass index influences fibromyalgia symptoms. Although previous studies report associations between increased body mass index BMI and fibromyalgia symptoms , there is uncertainty as to whether this relationship is driven by physical factors, psychological factors, or both.

To assess these relationships in a clinical sample of patients with fibromyalgia. Cross-sectional study. Tertiary care facility. A total of patients from an existing national fibromyalgia registry. FIQ-R overall impact subscale.

Asthma Symptom Utility Index : Reliability, validity, responsiveness and the minimal important difference in adult asthma patients. Bime, Christian; Wei, Christine Y. Background The evaluation of asthma symptoms is a core outcome measure in asthma clinical research.

Objectives We assessed the reliability, validity, and responsiveness to change of the ASUI in a population of adult asthma patients. Demographic information, spirometry, ASUI scores, and other asthma questionnaire scores were obtained at baseline and during follow-up visits. Participants also kept a daily asthma diary. Test-retest reliability was 0.

The frequency of heartburn, chest pain, epigastric pain, nausea, vomiting and belching was compared between the groups in the study sample and within three BMI categories. Raw associations analysis showed that heartburn: OR: 1. Meanwhile, according to BMI, in those with obesity, heartburn was more frequent in IBS and among those with overweight, epigastric pain and nausea were also more frequent in IBS. However, in an adjusted log linear model, no significant interaction was found between BMI and any other studied symptom and heartburn was found to be independent of IBS: 1,4 0.

The link between symptoms of office building occupants and in-office air pollution: the Indoor Air Pollution Index. The lack of an effective indoor air quality IAQ metric causes communication concerns among building tenants the public , building managers decision-makers , and IAQ investigators engineers.

The index , simple and easily understood, employs the range of pollutant concentrations and concentrations in the subject building to estimate a unitless single number, the IAPI, between 0 lowest pollution level and best IAQ and ten highest pollution level and worst IAQ. The index provides a relative measure of indoor air pollution for office buildings and ranks office indoor air pollution relative to the index distribution of the US office building population.

Furthermore, the index associates well with occupant symptoms , percentage of occupants with persistent symptoms. A tree-structured method is utilized in conjunction with the arithmetic mean as the aggregation function. The hierarchical structure of the method renders not only one index value, but also several sub- index values that are critical in the study of an office air environment.

The decomposition of the index leads to the ranking of sampled pollutants by their relative contribution to the index and the identification of dominant pollutant s. This information can be applied to design an effective strategy for reducing in-office air pollution. The management of acute uncomplicated cystitis in adult women by family physicians in Canada.

A cross-Canada study of adult women with symptoms of acute cystitis seen by primary care physicians was conducted to determine current management practices and first-line antibiotic choices. Physicians completed a standardized checklist of symptoms and signs, indicated their diagnosis and antibiotics prescribed. A urine sample for culture was obtained. Most women of , for whom clinical information about antibiotic prescriptions was available reported either frequency, urgency or painful urination.

Physicians would have usually ordered a urine culture for The urine culture was negative for The effect of current prescribing patterns on community levels of quinolone-resistant Escherichia coli may need to be monitored. Intravesical instillation of glycosaminoglycans is a promising option for the treatment of chronic cystitis , as it supports the regeneration of the damaged urothelial layer. We investigated the efficacy of short-term intravesical chondroitin sulphate treatment six courses of instillation in patients with chronic radiotherapy- or chemotherapy-associated cystitis.

This prospective, observational study included patients with chronic radiotherapy- or chemotherapy-associated cystitis , who received six once-weekly intravesical instillations of 0. Every week, patients recorded their symptoms and their benefits and tolerance of treatment, using a self-completed questionnaire.

The study included 16 patients mean age During the study, a reduction in all evaluated parameters was observed. Haematuria, present in 9 of the 16 patients at baseline, was completely resolved in all cases after 6 weeks. No treatment-related adverse events were reported. Intravesical administration of chondroitin sulphate was effective for the treatment of radiotherapy- or chemotherapy-associated cystitis. Even short-term treatment appears to be effective in reducing symptoms and improving the quality of life of patients.

Metabolic health and positive symptom severity has been investigated in schizophrenia, but not in clinical high risk CHR patients. However, in the smaller sample of CHR patients taking an antidepressant or antipsychotic, BMI was negatively correlated with positive symptoms. Although potentially underpowered, these preliminary findings provide initial steps in elucidating the relationships between metabolic health, neurochemistry, and symptom severity in CHR patients.

Fifty-one protocols were deemed valid. Participants were split into two groups based on extreme elevations on RC1; the high RC1 group produced higher scores on 39 scales including clinically significant elevations on 17 scales. This knowledge about the psychological characteristics of IC patients may have clinical utility for physicians and other treatment providers.

The results argue strongly for psychological evaluation as a component of IC diagnosis and treatment. Those with significant emotional overlay to their somatic complaints may be best managed through psychological interventions and minimally invasive treatments. Treatment of radiation-induced cystitis with hyperbaric oxygen. The effects of hyperbaric oxygen on radiation cystitis have been documented in 3 patients with radiation-induced hemorrhagic cystitis refractory to conventional therapy.

Cessation of gross hematuria and reversal of cystoscopic bladder changes were seen in response to a series of hyperbaric oxygen treatments of 2 atmosphere absolute pressure for 2 hours. To our knowledge this is the first report of cystoscopically documented healing of radiation-induced bladder injury.

Nurses have a high prevalence of musculoskeletal symptoms from patient handling tasks such as lifting, transferring, and repositioning. Comorbidities such as musculoskeletal symptoms may negatively affect engagement in leisure-time physical activity LTPA. However, limited data are available on the relationship between musculoskeletal symptoms and LTPA among nurses. The purpose of this study was to describe musculoskeletal symptoms and LTPA, and to examine the relationships of musculoskeletal symptoms , sociodemographics, and body mass index with LTPA among nurses.

Cross-sectional data on sociodemographics, employment characteristics, musculoskeletal symptoms , body mass index , and LTPA were collected from a statewide random sample of California nurses from January to July Descriptive statistics, bivariate and multiple logistic regressions were performed. This study found no evidence that musculoskeletal symptoms may interfere with regular engagement in LTPA.

Physical activity promotion interventions should address employment-related barriers, and particularly target racial minority nurses and those who have a high body mass index. Response to stress is determined in part by genetically influenced regulation of the monoamine system MAOA. We examined the interaction of a stressor receipt of public assistance and a gene regulating MAOA in the prediction of change in adolescent depressive symptoms and body mass index BMI. Participants were drawn from the National….

Few studies demonstrate how the index trauma may influence subsequent post-traumatic stress disorder PTSD symptoms , especially among soldiers. There is still no consensus on specific trauma types and their corresponding PTSD symptom profiles. Importantly, the significance of the military culture's possible influence on soldiers' PTSD has also been underexplored. Hence, this study aims to reach an understanding into how index trauma and military culture may possibly shape participants' PTSD expressions.

Case study design was used, wherein multiple sources of data-such as PTSD assessments, and interviews with the participants and key informants-enabled data triangulation. The three case reports are the outcomes of the corroboration of evidences that reveal an enriched and holistic understanding of the phenomenon under study.

The participants were three Filipino active duty combat soldiers. Although all participants had similar index traumas, their PTSD symptom expressions are unique from one another, in that they differ in terms of their most incapacitating PTSD symptoms and other symptoms that have been potentially shaped by military culture. Their most incapacitating symptoms : hypervigilance case 1 , negative belief in oneself and negative emotions case 2 , prolonged distress, and marked physiological reactions to trauma-related cues case 3 , may be understood in the light of how they personally experienced different circumstances of their index traumas.

The way participants have anchored specific components of their sworn soldier's creed i. Do biographical factors have a relevant impact on the disease course? The present study explores the influence of psychosocial adversities on the etiology and progress of interstitial cystitis IC.

Essentially a descriptive evaluation was performed. Thirty IC patients who fulfilled the current diagnostic criteria participated in the study. The investigation showed higher values for relevant childhood adversities in IC patients. A poor emotional relationship with both parents, chronic diseases of the parents, and physical maltreatment were frequently reported. In the cumulative adverse childhood experience score IC patients showed higher levels than published data of healthy control groups.

The contemporary social history did not show relevant psychosocial adversities. The quality of life is extremely reduced because of IC symptoms. The BSI showed high levels especially in the dimensions somatization, anxiety, and phobic anxiety.

The results of this study argue for a participatory role of psychosomatic factors in the assumed multifactorial etiology of interstitial cystitis. Background: Omega-3 n—3 fatty acid FA consumption is thought to improve depressive symptoms.

However, current evidence is limited, and whether this association exists among Puerto Ricans, a population burdened by depression, remains uncertain. We calculated the omega-3 index as the sum of eicosapentaenoic and docosahexaenoic acids, expressed as a percentage of total FAs. Statistical analyses included linear and logistic regression.

Effects of the body mass index on menopausal symptoms among Asian American midlife women using two different classification systems. To explore the effects of the body mass index BMI on menopausal symptoms among Asian American midlife women using two different classification systems: the international classification and the BMI classification for public health action among Asian populations.

Secondary analysis using data from two large Internet survey studies. Communities and groups of midlife women on the Internet. A total of Asian American midlife women who were recruited over the Internet. The Midlife Women's Symptom Index and self-reports of height and weight were used to collect data. The data were analyzed using multiple analyses of covariance. No significant differences in the prevalence and severity scores among three subscales and total menopausal symptoms according to the international classification were found.

When the BMI classification for public health action among Asian populations was used as an independent variable, significant differences were found in the severity scores of three subscales and total menopausal symptoms.

Results of the post-hoc analyses showed that Asian American midlife women who were in the BMI classification for high risk had significantly more severe menopausal symptoms than those who were in the BMI classification for increased risk. Nurses need to consider the BMI classification for Asian populations when they develop interventions to prevent and alleviate menopausal symptoms among Asian American midlife women.

Emphysematous cystitis : a rare cause of gross hematuria. Emphysematous cystitis is a relatively rare infectious condition of the urinary bladder. The mortality rate is high if the diagnosis is delayed or if the treatment is inadequate. We present an uncommon case of emphysematous cystitis and highlight the risk factors for this disease. An year-old man with a past medical history of type 2 diabetes and a central pontine infarction presented to the Emergency Department due to gross hematuria.

Computed tomography CT and plain radiography revealed localized gas within the bladder that was compatible with the diagnosis of emphysematous cystitis. A Foley catheter was inserted. Urine culture grew Klebsiella pneumoniae; 2 g cefotaxime daily was initiated. Subsequent plain radiography and CT scan showed regression of intraluminal gas.

We recommend CT for the definitive diagnosis of emphysematous cystitis. Adequate antibiotic therapy, strict blood glucose control, adequate drainage of urine, and early goal-directed therapy for suspected sepsis are suggested to prevent the complications of emphysematous cystitis. Balasubramanian, Raji; Pagoto, Sherry L.

I was not involved in any of the Brazilian projects. For example, it has been suggested in one of the posts that I was harsh for requiring the men to book-in at hrs when the norm was hrs. It was important to ensure, and the rules required, that the men get enough rest. As such, I asked them to come back at hrs and not hrs. I set high standards for the unit as a CO commanding officer. I believe in working together and I did not ask the men to do something I was not prepared to do myself.

However, like many others who live in apartments, I know some neighbours better than others and interact with some more than others. Florida Panthers assistant general manager Brett Peterson joined the Yahoo Sports Hockey Podcast to talk about his experience in hockey, the NHL's inclusivity issues, his transition from agent to executive, and the hot start in Sunrise.

He was The Chiefs will have to deal with the Super Bowl loser's hangover next season. Texas Tech head coach Chris Beard actually sat on the floor and mimicked an opposing player during a ridiculous on-court meltdown. Serena Williams is in prime form to start Australian Open play. Florida Panthers assistant general manager Brett Peterson has had a largely positive experience at every stage of his hockey career, and he believes the game is taking the right steps forward to ensure that for all individuals.

Britt Reid remains under investigation for a crash that left a 5-year-old girl in critical condition with brain injuries. Toronto Raptors forward Pascal Siakam has struggled from three-point range this year, but hit five threes against Memphis and explained what was different in the win.

MIAMI — It was only a week ago when the Miami Heat emerged from a long postgame locker room meeting following another disappointing loss, privately promising one another they would do more and publicly vowing to be better.

They were then and reeling. Beating Washington once and New York twice hardly is cause for a parade, but those victories might be a needed kick-start for the reigning Eastern Conference champions. We have a very tough-minded group. Veteran guards Goran Dragic and Avery Bradley are both injured and out for at least a few more games.

At , nobody is happy. From afar, it looked like an injury. A week ago, nothing was funny for the Heat. Things changed quickly. For about a week and a half, all the Heat will have to rely on is one another. The trip will have a very us-against-the-world vibe for the Heat, and Butler likes that. I want to win all of them, to tell you the truth. Canadian speedskaters are relishing a bit of normalcy in an abnormal season. The 13 who travelled to Heerenveen, Netherlands, for their first international races in 10 months did so with scant training on an indoor oval.

But 11 medals in a pair of World Cups there, including two gold, boosts morale heading into the world long-track championship starting Thursday at the same Dutch oval. More than medals, the Canadians are revelling in a return to hard training in an indoor oval, and getting a chance to express that work by racing. We feel like kids again every day," Laurent Dubreuil said. The COVID pandemic crushed the international racing calendar this winter as it has in many other sports.

Canada's long-track season will consist of January's two World Cups and this week's world championship in Heerenveen's Thialf oval. The short-track team won't get any World Cup races this winter because all were cancelled, although March's world championship remains on the schedule. Speed Skating deliberated on whether to send long-track athletes to Holland in the global pandemic, but some skaters felt desperate for competition a year out from the Winter Olympics in Beijing.

A lot of athletes wrote me and said they wanted to go. They've been without ice at their national training base, Calgary's Olympic Oval, since September because of a mechanical failure. Ice will not be restored there until spring. The athletes followed a makeshift schedule of dryland training, skating outdoors, short-track workouts and two weeks at a B.

Dubreuil, of Quebec City, also doesn't have access to an indoor oval in his hometown because one is currently under construction on the site of the previous oval. He often travels to Calgary for national-team camps, but ice isn't available there either.

Despite suboptimal preparation, Dubreuil earned a silver medal and two bronze in the men's , plus another bronze in the 1, in the two World Cups. The year-old compensated for lack of ice time by analyzing video of his good and bad races, and daily visualization of himself racing. I didn't know we would do necessarily as well as we have. I thought 'am I still going to be as good as I was last season? Reigning men's 5,metre world champion Ted-Jan Bloemen of Calgary finished off the podium in his individual World Cup races, although he helped Canada win a silver medal and a bronze in team pursuit.

Blondin chose not to compete in the 3, metres this season. The Canadians are largely confined to their hotel and the oval, but are allowed outdoor cycling workouts. Donna Spencer, The Canadian Press. A few days into training for the upcoming SheBelieves Cup in the warmth of Orlando, Florida, the Canadian women's soccer team has shared the requisite happy tears, belly laughs and of course, the shake-off-the-rust practise sessions.

Now, it's time for the real work to begin. The national team has been in an month standstill due to the coronavirus pandemic, and now, in its first camp since March , has just six months to chase a third-straight Olympic medal at this summer's Tokyo Games.

So what exactly is new head coach Bev Priestman expecting out of her first Canadian camp? There's a whole group of players who aren't yet in season and so I think just getting back on the ground and building some of the ideas … and then we're into a back-to-back tournament setting, which is exactly where [we] want to be, playing some of the best teams in the world. This year, due to Covid restrictions, Canada also No. Canada's European-based players will join the rest of the squad this weekend and the roster will be trimmed to 23 just before Canada opens against its longtime rival, the U.

New faces look to make impression There is a freshness to this first camp of

BOOKIE BETTING WEBSITES PAYPAL

Patients completed quality-of-life and performance status measures. A item index was produced from symptoms that were rated as most important by patients or clinicians. Preliminary evidence suggests that the total score and DRS and FWB subscales are reliable and valid as summary indexes. The TSE subscale may be least relevant given the advent of newer therapies.

Depressive symptoms mediate the association between fear of crime and higher body mass index. To investigate pathways in the association between fear of crime and obesity. A cross-sectional survey was administered among residents aged 18 years and older across all Census tracts. Genesee County, Michigan. A total of residents. Body mass index BMI was calculated by using the respondents' reported height and weight. Composite fear-of-crime and depressive symptoms scores were calculated by using several survey items.

Path analysis examined the effects of fear of crime on BMI. Fear of crime was associated with higher BMI. Depressive symptoms mediated the relationship between fear of crime and BMI p symptoms and BMI p symptoms , which in turn were associated with reduced exercise and subsequently higher BMI. Correlation between vocal tract symptoms and modern singing handicap index in church gospel singers.

To verify the correlation between vocal tract discomfort symptoms and perceived voice handicaps in gospel singers, analyzing possible differences according to gender. All participants answered two questionnaires: Vocal Tract Discomfort VTD scale and the Modern Singing Handicap Index MSHI that investigates the vocal handicap perceived by singers, linking the results of both instruments p symptoms , the higher the vocal handicap for singing.

Female gospel singers present higher frequency and intensity of vocal tract discomfort symptoms , as well as higher voice handicap for singing than male gospel singers. The higher the frequency and intensity of the laryngeal symptoms , the higher the vocal handicap will be. Fluorescein angiography of the bladder: technique and relevance to bladder cancer and interstitial cystitis patients.

Fluorescein angiography has been used in the study of bleeding vessels, neovascularity, tumors and ischemic tissues in a variety of disorders. This pilot study was designed to evaluate the feasibility, safety and relevance of this interesting technology for the evaluation of bladder wall vessels in patients with interstitial cystitis and bladder cancer.

Five patients with National Institutes of Health defined interstitial cystitis symptoms and 10 with bladder cancer were studied during cytoscopy while they were under general anesthesia. A yellow-green barrier filter nm.

Patients received a 5 ml. After hydrodistension, glomerulations in interstitial cystitis patients were more prominent with fluorescein angiography and occurred in the venule phase. Areas of papillary transitional cell tumor and carcinoma in situ developed a brilliant yellow-green fluorescence. Adjacent normal urothelium was nonfluorescent and provided a contrasting dark background facilitating the detection of all lesions. No allergic reaction or other adverse effect related to the fluorescein injection was observed.

These unique observations in a limited number of patients suggest that fluorescein angiography of the bladder is a safe and simple procedure. This preliminary report underscores the relevance of fluorescein angiography in the detection of bladder tumor and offers a new approach to the evaluation of bladder wall vessels in interstitial cystitis patients. Anxiety Sensitivity Index ASI-3 subscales predict unique variance in anxiety and depressive symptoms.

Anxiety sensitivity AS has been implicated in the development and maintenance of a range of mental health problems. The development of the Anxiety Sensitivity Index - 3, a psychometrically sound index of AS, has provided the opportunity to better understand how the lower-order factors of AS - physical, psychological, and social concerns - are associated with unique forms of psychopathology.

The present study investigated these associations among 85 treatment-seeking adults with high AS. Participants completed measures of AS, anxiety, and depression. Multiple regression analyses controlling for other emotional disorder symptoms revealed unique associations between AS subscales and certain types of psychopathology. Only physical concerns predicted unique variance in panic, only cognitive concerns predicted unique variance in depressive symptoms , and social anxiety was predicted by only social concerns.

Findings emphasize the importance of considering the multidimensional nature of AS in understanding its role in anxiety and depression and their treatment. Associations between depressive symptoms , self-efficacy, eating styles, exercise and body mass index in women. This article explores cross-sectional associations between depressive symptoms and body mass index BMI in women working in schools in the Greater New Orleans area. Self-efficacy for eating and exercise, eating styles, and exercise are examined as potential pathways.

This is a secondary data analysis of women who were participating in a workplace wellness randomized controlled trial to address environmental factors influencing eating and exercise behaviors using baseline data prior to the intervention. BMI was the primary outcome examined. Path analysis suggested that increased depressive symptoms were associated with increased BMI in women.

Indirect effects of depressive symptoms on BMI were found for increased healthy eating self-efficacy, increased emotional eating, and decreased exercise self-efficacy. The association between greater healthy eating self efficacy and BMI was unexpected, and may indicate a suppressor effect of eating self-efficacy in the relationship between depressive symptoms and BMI in women. The findings suggest the importance of depressive symptoms to BMI in women.

Targets for interventions to reduce BMI include targeting depressive symptoms and related sequelae including self-efficacy for exercise, and emotional eating. Further investigation of eating self-efficacy and BMI are recommended with particular attention to both efficacy for health eating and avoidance of unhealthy foods.

Forty-two patients with more than 2 episodes of cystitis in the proceeding 6 months were treated for 3 months with one capsule daily of ECE and observed for a further 6 months. The primary efficacy criterion was the number of episodes of recurrent cystitis during the 6 months after treatment compared to those during the 6 months before treatment. At the end of the 9-month trial, 34 patients all women were eligible for statistical analysis.

Their mean age was The number of recurrences was significantly lower during the 6-month follow-up period than during the 6 months preceding the trial 0. There were no serious adverse events related to the study drug. Our study demonstrates the efficacy and safety of ECE in the prophylactic treatment of chronically recurrent cystitis. Distribution of mast cell subtypes in interstitial cystitis : implications for novel diagnostic and therapeutic strategies?

To identify the presence and geographical distribution of mast cell MC subtypes: MC T tryptase positive-chymase negative and MC TC tryptase positive-chymase positive in bladder tissue. Stained sections were photographed, and positively stained MCs were quantified using ImageJ. Data were analysed using descriptive statistics and individual paired t-tests.

There was a significant difference in the density of MCs between each layer of the disease bladder, with the greatest accumulation within the detrusor p cystitis. Our results suggest that mastocytosis is present within all layers of disease bladder, especially the muscle layer. A high influx of MC TC in the mucosa of individuals who also had ulceration noted within their diagnostic notes may be of the Hunner's ulcer subclassification.

No commercial use is permitted unless otherwise expressly granted. Clemens, J. Quentin; Clauw, Daniel J. However, no studies have directly compared the characteristics of these syndromes in men and women.

However, a substantial proportion of men also report these types of bladder symptoms. A total of 17 studies enrolling patients were identified. Pooled analyses demonstrated that SNM was associated with great reduction in pelvic pain weighted mean difference [WMD] The management of interstitial cystitis IC is predominantly the reduction of the symptoms of frequency, urgency, and pain. Multimodal treatment approaches for IC are helpful in customizing therapy for individual patients.

Complementary and alternative therapies are a quintessential addition to the therapeutic armamentarium and frequently include dietary modification, nutraceuticals, bladder training, neuromodulation, stress reduction, and sex therapy. Dietary modification involves elimination of bladder irritants, fluid regulation, and a bowel regimen. Nutraceuticals studied for the treatment of IC include calcium glycerophosphate, L-arginine, mucopolysaccharides, bioflavinoids, and Chinese herbs.

Bladder training is effective after pain reduction. The neuromodulation of high-tone pelvic-floor muscle dysfunction is achieved with physical therapy and acupuncture. Stress reduction and sex therapy are best administered by a qualified stress manager and sex therapist. Multimodal, nonconventional management may add efficacy to the treatment of IC.

Performance of the American Urological Association Symptom Index with and without an additional urge incontinence item. We correlated the items and scales and examined whether adding the UI question resulted in better prediction of disease-specific health status. Eighteen women with advanced ovarian cancer completed the NFOSI and participated in cognitive interviews to assess: a the understandability of the NFOSI; and b the things patients have in mind when responding to the item, "I am bothered by side effects of treatment;" and c the interpretation patients place on items relating to fatigue and lack of energy.

Interviews were recorded and transcribed for qualitative analysis. When responding to the item, "I am bothered by side effects of treatment," fatigue, nausea, and neuropathy constituted the most frequently mentioned concerns.

Among the participants who were asked, eight participants responded that "fatigue" and "lack of energy" were the same concept and nine responded they were different. Participants associated "fatigue" with tiredness and associated "lack of energy" with the inability to perform daily tasks and activities.

Item revisions, deletions or additions do not appear warranted. Recurrent uncomplicated cystitis in women: allowing patients to self-initiate antibiotic therapy. Acute uncomplicated cystitis is a lower urinary tract infection occurring in the absence of anatomic or functional abnormalities of the urinary tract or any other complicating factors. The organism responsible is often an enterobacterium, especially Escherichia coli. What is the role of antibiotic therapy for non-pregnant women with recurrent acute uncomplicated cystitis?

We reviewed the available evidence using the standard Prescrire methodology. A single oral dose of fosfomycin trometamol is the antibiotic of choice for treating an episode of acute uncomplicated cystitis. Alternative antibiotics are certain fluoroquinolones or co-trimoxazole a fixed-dose combination of sulfamethoxazole and trimethoprim. For recurrent acute uncomplicated cystitis , cranberry juice has modest efficacy in reducing the frequency of episodes.

A number of non-drug measures are typically proposed, although their effects are unproven: drinking sufficient fluids and urinating regularly; urinating after sexual intercourse; and avoiding spermicides. The strategy that results in the lowest antibiotic exposure is a short course of antibiotics for each episode of urinary tract infection, initiated as soon as clinical symptoms appear.

Long-term antibiotic therapy is sometimes offered. According to one systematic review, women taking long-term prophylactic antibiotic therapy had about 6 times fewer clinical recurrences than with placebo. According to one randomised trial, 3 g of fosfomycin trometamol taken as a single dose every ten days reduced the frequency of recurrence, resulting in 0.

When cystitis appears to be associated with sexual intercourse, two small randomised trials suggest that routine postcoital antibiotic treatment is more effective. Gastroesophageal reflux may contribute to the development of cricopharyngeal dysfunction and Zenker's diverticulum.

Common dictum suggests that if upper esophageal sphincter tone is reduced through cricopharyngeal myotomy, symptoms of laryngopharyngeal reflux may worsen. We hypothesized that patients who undergo myotomy should show decreased dysphagia symptoms with concurrent worsening of reflux symptomatology and that these changes would be greater in those patients undergoing complete versus partial myotomy.

A retrospective chart review was performed for patients who underwent endoscopic or open cricopharyngeal myotomy, with or without Zenker's diverticulectomy. Patients who underwent partial myotomy via endoscopic stapling of Zenker's diverticulum were compared with patients who underwent complete myotomy either endoscopic laser-assisted or via an open transcervical approach.

The patients were further subdivided into three groups for data analysis: endoscopic staple diverticulotomy, laser cricopharyngeal myotomy, and open approach. A total of 41 patient charts were reviewed. Of these 41 patients, 17 underwent endoscopic stapler-assisted diverticulotomy, 4 underwent endosopic laser-assisted cricopharyngeal myotomy, and 20 underwent open transcervical cricopharyngeal myotomy, with diverticulectomy as indicated.

Mean pre- and postoperative RSIs were Concern for worsening of reflux symptoms following surgery does not appear to be clinically common. Published by. Background Overweight and obese individuals are at increased risk for gastroesophageal reflux disease GERD. We observed a dose-dependent relationship between increasing BMI and frequent reflux symptoms multivariate P for trend symptoms OR 2. Our findings suggest that even modest weight gain among normal weight individuals may cause or exacerbate reflux symptoms.

This study examined the association between body mass index BMI changes over time and the risk of elevated depressive symptoms in a cohort of Midwestern rural adults. The longitudinal study used data from a telephone survey in including 1, men and women enrolled in the Walk the Ozarks to Wellness Project from 12 rural communities in Missouri, Arkansas, and Tennessee.

For each unit increase in BMI over time, representing an average increase of about 5. Our findings hold important public health implications given the increasing rates of overweight and obesity over the past couple of decades, particularly among rural adults.

BK virus-associated hemorrhagic cystitis in a pediatric lung transplant recipient. BKV was first postulated to be a potential pathogen in when it was isolated in the urine of a renal transplant recipient. The pathology of BKV is generally confined to the urinary tract. In renal transplant recipients, BKV has been associated with hemorrhagic cystitis , urethral stenosis, and interstitial nephritis. Reports of BKV infection in lung transplant recipients are limited to a few case reports in adult patients.

To our knowledge, there are no published reports of pediatric lung transplant recipients with BKV-associated hematuria. We hereby report a case of BKV-induced hemorrhagic cystitis in a pediatric lung transplant recipient. Koufman proposed the term to designate Laryngeal Pharyngeal Reflux LPR symptoms , signs or tissue damage resulting from aggression of the gastrointestinal contents in the upper aerodigestive tract. Belafsky et al proposed a score that points to inflammatory laryngeal signs through videolaryngoscopic findings, the Reflux Finding Score RFS.

The objective of this study is to provide a comparison between the Reflux Finding Score and the Reflux Symptom Index in the practice of Otorhinolaryngology. We excluded nine patients and the study group was patients. The study group consisted of patients 88 women and 38 men.

Their main complaints were cough The RSI ranges from 13 to 42 with a mean of The RFS ranged from 3 to 19 with a mean of 9. Based on the clinical index , the specialist can evaluate the need for further tests. Ultrasonography in the diagnosis of hemorrhagic cystitis — a complication of bone marrow transplantation in pediatric oncology patients.

Objective The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children. Material and methods The study involved an analysis of clinical material and the results of imaging tests performed in patients who underwent hematopoietic cell transplantation.

Ultrasonographic findings in 42 patients with hemorrhagic cystitis were analyzed in detail. The ultrasound images served to assess the severity of hemorrhagic cystitis and the results were compared with the clinical assessment of the disease on the Droller scale, as well as the laboratory and endoscopic tests.

Results In the studied group of patients hemorrhagic cystitis following allogeneic transplantation was diagnosed in The study revealed a higher incidence of hemorrhagic cystitis in children above 10 years of age. Grade 3 according to the Droller was diagnosed in The number of ultrasound examinations depended on the clinical symptoms , severity, duration and co-occurrence of other complications following the transplantation and was within the 1—15 range average: 4.

Grades 3 and 4 were related to the poor clinical condition of the patients and to their longer hospitalization. During this period there was an increased risk of renal malfunction and acute renal failure, post-inflammatory narrowing of the ureters, hydronephrosis, and in grade 4 the fibrosis of the bladder with reduced bladder capacity.

Analyses demonstrated a significant correlation between the ultrasound image of the bladder wall and the clinical severity. Conclusions Ultrasound with Doppler options remains the primary diagnostic tool in the evaluation of hemorrhagic cystitis , and is useful in terms of its diagnosis, determination of the severity, and.

The objective of the present study was to evaluate the effectiveness of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract NDM , when associated to antibiotic therapy, in reducing the persistence of recurrent cystitis in this risk population. Patients and Methods: Sixty breast cancer survived women with recurrent cystitis were retrospectively examined.

Group 1, comprised of 40 patients treated with antibiotic therapy associated with NDM lasting for six months, Group 2 comprised of 20 patients treated with antibiotics alone. Results: The use of NDM in combination with antibiotic therapy showed a significant reduction in positive urine cultures, compared to antibiotics alone. Subjects of Group 1 rather than those of Group 2, showed improvement in symptoms score of urgency, frequency, urge incontinence, recurrent cystitis , bladder and urethral pain.

Conclusion: In breast cancer survived women affected by genitourinary discomfort, the combination of NDM and antibiotic therapy showed a greater efficacy in reducing urinary tract infections and urinary discomfort with respect to antibiotic use only. Breast cancer survivors in adjuvant therapy, frequently experience the estrogen deficiency with genitourinary symptoms mostly represented by recurrent bacterial cystitis. Sixty breast cancer survived women with recurrent cystitis were retrospectively examined.

The use of NDM in combination with antibiotic therapy showed a significant reduction in positive urine cultures, compared to antibiotics alone. In breast cancer survived women affected by genitourinary discomfort, the combination of NDM and antibiotic therapy showed a greater efficacy in reducing urinary tract infections and urinary discomfort with respect to antibiotic use only.

George J. Delinasios , All rights reserved. The bladder pain syndrome BPS is a spectrum of urological symptoms characterised by bladder pain with typical cystoscopic features. Diagnosis and management of this syndrome may be difficult.

There is no evidence-based management approach for the diagnosis or treatment of BPS. The objective of this study was to critically review and summarise the evidence relating to the diagnosis and treatment of the bladder pain syndrome. A review of published data on the diagnosis and treatment of the BPS was performed. Our search was limited to English-language articles, on the "diagnosis", and "management" or "treatment" of "interstitial cystitis " and the "bladder pain syndrome" in "humans.

All urodynamic volumes are reduced in patients with BPS. Associated conditions include psychological distress, depression, history of sexual assault, irritable bowel syndrome and fibromyalgia. Cystoscopy remains the test for definitive diagnosis, with visualisation of haemorrhage on cystoreduction. A multidisciplinary treatment approach is essential in the management of this condition.

Orally administered amitriptyline is an efficacious medical treatment for BPS. Sacral or pudendal neuromodulation is effective, minimally invasive and safe. Surgery is reserved for refractory cases. There remains a paucity of evidence for the diagnosis and treatment of BPS. We encountered significant heterogeneity in the assessment of symptoms , duration of treatment and follow up of patients in our literature review. Chart reviews and telephone surveys were then conducted to determine their posttherapy course.

Of 68 eligible women, 55 Their mean age at therapy onset was At the end of the follow-up period, 19 of the 55 women Univariate and multivariate analyses showed that DMSO treatment failure was more likely in patients with pretreatment day-time urinary frequency more than 15 episodes per day OR 1. Prevention of Cystitis : Travelling between the Imaginary and Reality. As a preventive strategy, increased water intake is often recommended to women affected by recurrent cystitis ; however, clinical data are sparse and conflicting.

This review evaluates the preventive approaches used as alternatives to obtain relief from the burden of cystitis and focuses on the effect of fluid intake on urinary tract infection. Karger AG, Basel. Risk factors for recurrent cystitis following acute cystitis in female patients. We conducted a retrospective analysis of acute cystitis AC patients to evaluate the risk factors of recurrent cystitis RC patients following AC. The clinical records of subjects with a confirmed diagnosis of AC and 90 healthy subjects who visited the Health Promotion Center between and were reviewed.

A patient was diagnosed with RC if she was treated for three or more symptomatic episodes of cystitis over a month period. To examine the association between body mass index BMI and symptom severity and quality of life QOL in patients with fibromyalgia. Intravesical instillations were performed weekly in first month, every 15 days in the second month and monthly in third and fourth months, for a total of 8 doses.

All patients had a potassium sensitivity test PST initially. Wilcoxon and Mann-Whitney U tests were used for statistical analysis. In total, 53 patients met the study criteria. There were 30 patients in the HA-CS group mean age: The initial PST was positive in Eight patients had mild adverse events. An important limitation of our study is that the HA dosage of the 2 treatment arms were different. It would be more appropriate with same HA dosage in both groups; however, there was no commercially available glycosaminoglycan GAG substance with same HA dosage for single and combination therapy.

Large, long-term randomized studies. Further evidence for a broader concept of somatization disorder using the somatic symptom index. Both groups showed a qualitatively similar pattern of psychopathological comorbidity and had elevated scores on measures of depression, hypochondriasis, and anxiety. A good discrimination between mild and severe forms of somatization was found by using the SSI criterion.

The results provide further evidence for the validity of the SSI concept, which reflects the clinical relevance of somatization in addition to the narrow definition of somatization disorder. Decreased physical activity attributable to higher body mass index influences fibromyalgia symptoms.

Although previous studies report associations between increased body mass index BMI and fibromyalgia symptoms , there is uncertainty as to whether this relationship is driven by physical factors, psychological factors, or both. To assess these relationships in a clinical sample of patients with fibromyalgia. Cross-sectional study. Tertiary care facility. A total of patients from an existing national fibromyalgia registry.

FIQ-R overall impact subscale. Asthma Symptom Utility Index : Reliability, validity, responsiveness and the minimal important difference in adult asthma patients. Bime, Christian; Wei, Christine Y. Background The evaluation of asthma symptoms is a core outcome measure in asthma clinical research.

Objectives We assessed the reliability, validity, and responsiveness to change of the ASUI in a population of adult asthma patients. Demographic information, spirometry, ASUI scores, and other asthma questionnaire scores were obtained at baseline and during follow-up visits. Participants also kept a daily asthma diary. Test-retest reliability was 0.

The frequency of heartburn, chest pain, epigastric pain, nausea, vomiting and belching was compared between the groups in the study sample and within three BMI categories. Raw associations analysis showed that heartburn: OR: 1. Meanwhile, according to BMI, in those with obesity, heartburn was more frequent in IBS and among those with overweight, epigastric pain and nausea were also more frequent in IBS.

However, in an adjusted log linear model, no significant interaction was found between BMI and any other studied symptom and heartburn was found to be independent of IBS: 1,4 0. The link between symptoms of office building occupants and in-office air pollution: the Indoor Air Pollution Index.

The lack of an effective indoor air quality IAQ metric causes communication concerns among building tenants the public , building managers decision-makers , and IAQ investigators engineers. The index , simple and easily understood, employs the range of pollutant concentrations and concentrations in the subject building to estimate a unitless single number, the IAPI, between 0 lowest pollution level and best IAQ and ten highest pollution level and worst IAQ.

The index provides a relative measure of indoor air pollution for office buildings and ranks office indoor air pollution relative to the index distribution of the US office building population. Furthermore, the index associates well with occupant symptoms , percentage of occupants with persistent symptoms. A tree-structured method is utilized in conjunction with the arithmetic mean as the aggregation function.

The hierarchical structure of the method renders not only one index value, but also several sub- index values that are critical in the study of an office air environment. The decomposition of the index leads to the ranking of sampled pollutants by their relative contribution to the index and the identification of dominant pollutant s.

This information can be applied to design an effective strategy for reducing in-office air pollution. The management of acute uncomplicated cystitis in adult women by family physicians in Canada. A cross-Canada study of adult women with symptoms of acute cystitis seen by primary care physicians was conducted to determine current management practices and first-line antibiotic choices.

Physicians completed a standardized checklist of symptoms and signs, indicated their diagnosis and antibiotics prescribed. A urine sample for culture was obtained. Most women of , for whom clinical information about antibiotic prescriptions was available reported either frequency, urgency or painful urination. Physicians would have usually ordered a urine culture for The urine culture was negative for The effect of current prescribing patterns on community levels of quinolone-resistant Escherichia coli may need to be monitored.

Intravesical instillation of glycosaminoglycans is a promising option for the treatment of chronic cystitis , as it supports the regeneration of the damaged urothelial layer. We investigated the efficacy of short-term intravesical chondroitin sulphate treatment six courses of instillation in patients with chronic radiotherapy- or chemotherapy-associated cystitis.

This prospective, observational study included patients with chronic radiotherapy- or chemotherapy-associated cystitis , who received six once-weekly intravesical instillations of 0. Every week, patients recorded their symptoms and their benefits and tolerance of treatment, using a self-completed questionnaire. The study included 16 patients mean age During the study, a reduction in all evaluated parameters was observed. Haematuria, present in 9 of the 16 patients at baseline, was completely resolved in all cases after 6 weeks.

No treatment-related adverse events were reported. Intravesical administration of chondroitin sulphate was effective for the treatment of radiotherapy- or chemotherapy-associated cystitis. Even short-term treatment appears to be effective in reducing symptoms and improving the quality of life of patients. Metabolic health and positive symptom severity has been investigated in schizophrenia, but not in clinical high risk CHR patients.

However, in the smaller sample of CHR patients taking an antidepressant or antipsychotic, BMI was negatively correlated with positive symptoms. Although potentially underpowered, these preliminary findings provide initial steps in elucidating the relationships between metabolic health, neurochemistry, and symptom severity in CHR patients. Fifty-one protocols were deemed valid.

Participants were split into two groups based on extreme elevations on RC1; the high RC1 group produced higher scores on 39 scales including clinically significant elevations on 17 scales. This knowledge about the psychological characteristics of IC patients may have clinical utility for physicians and other treatment providers. The results argue strongly for psychological evaluation as a component of IC diagnosis and treatment.

Those with significant emotional overlay to their somatic complaints may be best managed through psychological interventions and minimally invasive treatments. Treatment of radiation-induced cystitis with hyperbaric oxygen. The effects of hyperbaric oxygen on radiation cystitis have been documented in 3 patients with radiation-induced hemorrhagic cystitis refractory to conventional therapy.

Cessation of gross hematuria and reversal of cystoscopic bladder changes were seen in response to a series of hyperbaric oxygen treatments of 2 atmosphere absolute pressure for 2 hours. To our knowledge this is the first report of cystoscopically documented healing of radiation-induced bladder injury.

Nurses have a high prevalence of musculoskeletal symptoms from patient handling tasks such as lifting, transferring, and repositioning. Comorbidities such as musculoskeletal symptoms may negatively affect engagement in leisure-time physical activity LTPA. However, limited data are available on the relationship between musculoskeletal symptoms and LTPA among nurses. The purpose of this study was to describe musculoskeletal symptoms and LTPA, and to examine the relationships of musculoskeletal symptoms , sociodemographics, and body mass index with LTPA among nurses.

Cross-sectional data on sociodemographics, employment characteristics, musculoskeletal symptoms , body mass index , and LTPA were collected from a statewide random sample of California nurses from January to July Descriptive statistics, bivariate and multiple logistic regressions were performed. This study found no evidence that musculoskeletal symptoms may interfere with regular engagement in LTPA.

Physical activity promotion interventions should address employment-related barriers, and particularly target racial minority nurses and those who have a high body mass index. Response to stress is determined in part by genetically influenced regulation of the monoamine system MAOA. We examined the interaction of a stressor receipt of public assistance and a gene regulating MAOA in the prediction of change in adolescent depressive symptoms and body mass index BMI. Participants were drawn from the National….

Few studies demonstrate how the index trauma may influence subsequent post-traumatic stress disorder PTSD symptoms , especially among soldiers. There is still no consensus on specific trauma types and their corresponding PTSD symptom profiles. Importantly, the significance of the military culture's possible influence on soldiers' PTSD has also been underexplored. Hence, this study aims to reach an understanding into how index trauma and military culture may possibly shape participants' PTSD expressions.

Case study design was used, wherein multiple sources of data-such as PTSD assessments, and interviews with the participants and key informants-enabled data triangulation. The three case reports are the outcomes of the corroboration of evidences that reveal an enriched and holistic understanding of the phenomenon under study. The participants were three Filipino active duty combat soldiers. Although all participants had similar index traumas, their PTSD symptom expressions are unique from one another, in that they differ in terms of their most incapacitating PTSD symptoms and other symptoms that have been potentially shaped by military culture.

Their most incapacitating symptoms : hypervigilance case 1 , negative belief in oneself and negative emotions case 2 , prolonged distress, and marked physiological reactions to trauma-related cues case 3 , may be understood in the light of how they personally experienced different circumstances of their index traumas. The way participants have anchored specific components of their sworn soldier's creed i. Do biographical factors have a relevant impact on the disease course?

The present study explores the influence of psychosocial adversities on the etiology and progress of interstitial cystitis IC. Essentially a descriptive evaluation was performed. Thirty IC patients who fulfilled the current diagnostic criteria participated in the study. The investigation showed higher values for relevant childhood adversities in IC patients. A poor emotional relationship with both parents, chronic diseases of the parents, and physical maltreatment were frequently reported.

In the cumulative adverse childhood experience score IC patients showed higher levels than published data of healthy control groups. The contemporary social history did not show relevant psychosocial adversities. The quality of life is extremely reduced because of IC symptoms.

The BSI showed high levels especially in the dimensions somatization, anxiety, and phobic anxiety. The results of this study argue for a participatory role of psychosomatic factors in the assumed multifactorial etiology of interstitial cystitis. Background: Omega-3 n—3 fatty acid FA consumption is thought to improve depressive symptoms. However, current evidence is limited, and whether this association exists among Puerto Ricans, a population burdened by depression, remains uncertain.

We calculated the omega-3 index as the sum of eicosapentaenoic and docosahexaenoic acids, expressed as a percentage of total FAs. Statistical analyses included linear and logistic regression. Effects of the body mass index on menopausal symptoms among Asian American midlife women using two different classification systems. To explore the effects of the body mass index BMI on menopausal symptoms among Asian American midlife women using two different classification systems: the international classification and the BMI classification for public health action among Asian populations.

Secondary analysis using data from two large Internet survey studies. Communities and groups of midlife women on the Internet. A total of Asian American midlife women who were recruited over the Internet. The Midlife Women's Symptom Index and self-reports of height and weight were used to collect data. The data were analyzed using multiple analyses of covariance. No significant differences in the prevalence and severity scores among three subscales and total menopausal symptoms according to the international classification were found.

When the BMI classification for public health action among Asian populations was used as an independent variable, significant differences were found in the severity scores of three subscales and total menopausal symptoms. Results of the post-hoc analyses showed that Asian American midlife women who were in the BMI classification for high risk had significantly more severe menopausal symptoms than those who were in the BMI classification for increased risk.

Nurses need to consider the BMI classification for Asian populations when they develop interventions to prevent and alleviate menopausal symptoms among Asian American midlife women. Emphysematous cystitis : a rare cause of gross hematuria. Emphysematous cystitis is a relatively rare infectious condition of the urinary bladder. The mortality rate is high if the diagnosis is delayed or if the treatment is inadequate. We present an uncommon case of emphysematous cystitis and highlight the risk factors for this disease.

An year-old man with a past medical history of type 2 diabetes and a central pontine infarction presented to the Emergency Department due to gross hematuria. Computed tomography CT and plain radiography revealed localized gas within the bladder that was compatible with the diagnosis of emphysematous cystitis. A Foley catheter was inserted. Urine culture grew Klebsiella pneumoniae; 2 g cefotaxime daily was initiated. Subsequent plain radiography and CT scan showed regression of intraluminal gas.

We recommend CT for the definitive diagnosis of emphysematous cystitis. Adequate antibiotic therapy, strict blood glucose control, adequate drainage of urine, and early goal-directed therapy for suspected sepsis are suggested to prevent the complications of emphysematous cystitis. Balasubramanian, Raji; Pagoto, Sherry L. We investigated whether depressive symptoms and antidepressant use are associated with biomarkers for glucose dysregulation and inflammation, body mass index BMI , and waist circumference.

We used multiple linear regression models to examine whether depressive symptoms and antidepressant use are associated with BMI, waist circumference, and biomarkers. Among women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance.

Analyses of baseline data from women showed that both elevated depressive symptoms and antidepressant use were associated with higher C-reactive protein levels. Monitoring body habitus and other biomarkers among women with elevated depression symptoms or taking antidepressant medication may be prudent to prevent diabetes and cardiovascular disease. Body mass index and depressive symptoms in older adults: the moderating roles of race, sex, and socioeconomic status.

Although the long-term health risks associated with obesity in older adults have been well documented, less is known about the psychological consequences. The current study examined the relationship between body mass index BMI and subsequent depressive symptoms. The authors anticipated that BMI would predict depressive symptoms , and that this relationship would be greater among women, individuals of higher socioeconomic status SES , and white subjects.

A three-year longitudinal epidemiological design was employed. A comprehensive survey assessed age, gender, race, SES education and income , and health functioning variables. BMI was derived from self-reported weight and height. BMI was found to predict depressive symptoms.

Contrary to predictions, the influence of BMI on depressive symptoms was greater for African Americans than whites and, in particular, African Americans with less education. There were no sex differences. Among older adults, BMI was associated with depressive symptoms although the effect size was small.

Factors contributing to this relationship may differ from those observed in younger populations, for example, health functioning may play a larger role. Obesity appears to have the most adverse impact on those who are most likely to be overweight, lower SES African Americans.

Patient-reported symptom scales are needed to evaluate treatments for gastroparesis. Symptomatic patients were started with a new treatment for gastroparesis. Responders were defined based on patient and clinician global rating of change. Minimal important differences MID were estimated based on baseline to 4 week changes in symptoms scores for small improvements. Of 69 patients participating, 46 had idiopathic, 19 diabetic, and four postfundoplication gastroparesis.

Composite-2 score nausea, early satiety, bloating, abdominal pain had a lower ES of 0. Symptoms of early satiety, nausea, postprandial fullness, and bloating were responsive to treatment for gastroparesis. A composite of these symptoms also demonstrates validity and responsiveness to treatment for gastroparesis, and may represent an acceptable endpoint for evaluating the effectiveness of medical treatments in clinical trials for gastroparesis.

Another aim of this research was to provide an example of how sex and gender could be included into the design of a health information system. This prototype will later undergo usability and content evaluation. IVES was conducted with high-frequency current impulses 2. As the result of exposure to both physical factors in the presence of standard medication, NDUB symptoms alleviated by E. Vishnevsky's criteria by Dopplerographic examination of renal vessels stated a The proposed complex pharmacological plus physiotherapeutic treatment of chronic pyelonephritis and cystitis in abnormal urodynamics resulted in a 2.

BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation. Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis , which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration.

However, late-onset hemorrhagic cystitis , which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem cell transplantation late-onset hemorrhagic cystitis , pediatricians outside the hemato-oncology and nephrology specialties tend to be unfamiliar with hemorrhagic cystitis and the BK virus. Moreover, no standard guidelines for the early diagnosis and treatment of BK virus-associated hemorrhagic cystitis after stem cell transplantation have been established.

Here, we briefly introduce poststem cell transplantation BK virus-associated hemorrhagic cystitis. We evaluated the potential for urinary chemokines to serve as measures of treatment response over time to SNM.

Collected urine was screened for infection by dipstick and analyzed for chemokines by luminex xMAP analysis. Urine levels of sIL-1ra Multivariable analysis of data revealed that sIL-1ra and MCP-1 together explained the majority of variance in data. These results. Relationships among participant international prostate symptom score, benign prostatic hyperplasia impact index changes and global ratings of change in a trial of phytotherapy in men with lower urinary tract symptoms.

We related changes in American Urological Association symptom index scores with bother measures and global ratings of change in men with lower urinary tract symptoms who were enrolled in a saw palmetto trial. To be eligible for study men were 45 years old or older, and had a peak uroflow of 4 ml per second or greater and an American Urological Association symptom index score of 8 to Participants self-administered the American Urological Association symptom index , International Prostate Symptom Score quality of life item, Benign Prostatic Hyperplasia Impact Index and 2 global change questions at baseline, and at 24, 48 and 72 weeks.

In participants global ratings of a little better were associated with a mean decrease in American Urological Association symptom index scores from 2. Changes in American Urological Association symptom index scores could discriminate between participants rating themselves at least a little better vs unchanged or worse.

Our findings support the practice of powering studies to detect group mean differences in American Urological Association symptom index scores of at least 3 points. To study the correlation between polyoma virus load and hemorrhagic cystitis after allogeneic stem cells transplantation for prevention of hemorrhagic cystitis. Genes of BKV and JCV was detectable in urine specimens of healthy persons and there was a correlation between the load of polyomavirus and incidence of hemorrhagic cystitis.

Treating acute cystitis with biodegradable micelle-encapsulated quercetin. Intravesical application of an anti-inflammatory drug is an efficient strategy for acute cystitis therapy. Quercetin QU is a potent anti-inflammatory agent; however, its poor water solubility restricts its clinical application.

Response to stress is determined in part by genetically-influenced regulation of the monoamine system. We examined the interaction of a stressor receipt of public assistance and a gene regulating the monoamine system MAOA in the prediction of change in adolescent depressive symptoms and body mass index BMI. We focused on males due to the fact that males only have one MAOA allele.

Growth curve analyses were conducted to assess the association between public assistance, MAOA allele, and their interaction and the intercept and slope of depressive symptoms and BMI. The results indicated that among males, MAOA allele type interacted with receipt of public assistance in the prediction of rate of change in both depressive symptoms and BMI from early adolescence through early adulthood.

Males with the short MAOA allele whose families received public assistance tended to experience increased growth in depressive symptoms and BMI. Implications of the findings for understanding the relations among stress, physiology, and development are discussed. Body mass index and depressive symptoms in primary care settings: examining the moderating roles of smoking status, alcohol consumption and vigorous exercise. Depressive symptoms and obesity are highly prevalent in primary care settings.

Depressive symptoms and obesity are positively related; as body weight increases, individuals are more likely to display depressive symptoms. This study examines the moderating roles of health behaviours alcohol use, smoking status and vigorous exercise on the relationship between body mass index and depressive symptoms.

Exercise attenuates the relationship between depressive symptoms and obesity. Primary care patients often report multiple health risk behaviours and symptoms , including obesity and depressive symptomatology. This study examined the relationship between body mass index BMI and depressive symptomatology among primary care patients and tested its moderation by health behaviours.

Using three multilevel models, we tested the moderation of health behaviours on the BMI-depressive symptoms relationship. After controlling for relevant covariates, BMI was positively related to depressive symptoms. Published This article is a U. Government work and is in the public domain in the USA. The Whiteley Index -7 WI-7 is frequently used for evaluating patients with suspected hypochondriasis.

This study investigated the psychometric properties of the Mandarin Chinese version of the WI-7 and its application to evaluation of somatic symptom and related disorders. Exploratory factor analysis was performed, and the test-retest reliability and the internal consistency of the WI-7 were assessed. Receiver Operating Characteristic curves were established, and the area under the curve was calculated to determine the cutoff point to distinguish DSM-IV somatoform disorders and DSM-5 somatic symptom and related disorders, respectively.

A total of subjects were recruited for this study. The exploratory factor analysis of the WI-7 identified a single factor. The internal consistency and test-retest reliability of the WI-7 were 0. The Mandarin Chinese version of the WI-7 is a potentially useful tool to detect individuals with DSM-5 somatic symptom and related disorders.

Polyomavirus BK: possibly associated skin eruption in a patient with hemorrhagic cystitis. A year-old girl with Fanconi anemia was submitted to allogeneic hematopoietic stem cell transplantation. Two weeks after the appearance of the urinary symptoms the patient presented numerous papules and vesicles on both hands and feet. The relationship of BKV with frequent infections in immunocompromised patients is well established.

The positive PCR of vesicular fluid suggests that this was the causative agent of the skin lesion in this case. Complementary and alternative medical therapies for interstitial cystitis : an update from the United States.

Patients with refractory and debilitating symptoms may respond to complementary and alternative medical treatments CAM. Through CAM therapies, practitioners assist the patient to be at the center of their care, empowering them to be emotionally and physically involved. Multi-disciplinary care, including urology, gynecology, gastroenterology, neurology, psychology, physiotherapy and pain medicine, is also identified to be the crux of adequate management of patients with chronic pelvic pain because of its variable etiology.

The purpose of this review is to emphasize these changes and discuss management strategies. Introduction This study aims to evaluate the effectiveness of kenalog injection into Hunner's lesions. Materials and Methods All patients had cystoscopy and bladder hydrodistention with corticosteroid injection into Hunner's lesions over a 2. Data include patient characteristics and pre- and post-operative validated questionnaires. Spearman Correlation and Wilcoxon t-tests were used for analysis.

Results One hundred patients were reviewed retrospectively. There was a 1. Urinary frequency decreased from a mean of Patients had improved frequency and nocturia 12 weeks post injection. This study aims to evaluate the effectiveness of kenalog injection into Hunner's lesions. All patients had cystoscopy and bladder hydrodistention with corticosteroid injection into Hunner's lesions over a 2. Spearman Correlation and Wilcoxon t -tests were used for analysis.

One hundred patients were reviewed retrospectively. Associations between body mass index , weight control concerns and behaviors, and eating disorder symptoms among non-clinical Chinese adolescents. The athletes followed a makeshift schedule of dryland training, skating outdoors, short-track workouts and two weeks at a B. Dubreuil, of Quebec City, also doesn't have access to an indoor oval in his hometown because one is currently under construction on the site of the previous oval.

He often travels to Calgary for national-team camps, but ice isn't available there either. Despite suboptimal preparation, Dubreuil earned a silver medal and two bronze in the men's , plus another bronze in the 1, in the two World Cups. The year-old compensated for lack of ice time by analyzing video of his good and bad races, and daily visualization of himself racing.

I didn't know we would do necessarily as well as we have. I thought 'am I still going to be as good as I was last season? Reigning men's 5,metre world champion Ted-Jan Bloemen of Calgary finished off the podium in his individual World Cup races, although he helped Canada win a silver medal and a bronze in team pursuit.

Blondin chose not to compete in the 3, metres this season. The Canadians are largely confined to their hotel and the oval, but are allowed outdoor cycling workouts. Donna Spencer, The Canadian Press. A few days into training for the upcoming SheBelieves Cup in the warmth of Orlando, Florida, the Canadian women's soccer team has shared the requisite happy tears, belly laughs and of course, the shake-off-the-rust practise sessions. Now, it's time for the real work to begin.

The national team has been in an month standstill due to the coronavirus pandemic, and now, in its first camp since March , has just six months to chase a third-straight Olympic medal at this summer's Tokyo Games. So what exactly is new head coach Bev Priestman expecting out of her first Canadian camp? There's a whole group of players who aren't yet in season and so I think just getting back on the ground and building some of the ideas … and then we're into a back-to-back tournament setting, which is exactly where [we] want to be, playing some of the best teams in the world.

This year, due to Covid restrictions, Canada also No. Canada's European-based players will join the rest of the squad this weekend and the roster will be trimmed to 23 just before Canada opens against its longtime rival, the U. New faces look to make impression There is a freshness to this first camp of Yes, there's a new coach, but also six uncapped invitees and a few other players with less than five appearances at the senior level.

This team has seen very little turnover since winning bronze at Rio Veterans Rhian Wilkinson and Melissa Tancredi hung up their cleats shortly after those Olympics and with a handful of others expected to do the same following Tokyo, Priestman is conscious of the need for new faces and new ideas.

Not only ahead of the Olympics, but also as they attempt to qualify for the next World Cup in , hosted by Australia and New Zealand. With so many well-established players on the senior team, Priestman said she can't predict whether some of these new faces might make the final player roster for Tokyo, but this is their chance to knock on the door.

Essential to the culture of the Canadian team is the work done over the last 15 years by the senior leadership, some which are still playing Christine Sinclair, Diana Matheson, Erin McLeod, Sophie Schmidt, Desiree Scott , and those who've retired Wilkinson, Tancredi. The veteran group has always made sure that the next generation coming in feels as much a part of the team as those who have been around for over a decade — an integral component to their success.

Priestman saw it first-hand when she was an assistant under former coach John Herdman. The reality of the pandemic has meant adapting, whether that's been watching games on TV rather than in-person, holding virtual one-on-ones or group culture meetings, or spending more time writing reports on players and comparing them with other staff members.

Having a tournament setting against top-tier nations like the U. We have to go in and apply some things that we want to apply for the Olympic Games, we can't go in and say we're going to do what we've always done," Priestman said. Heinicke was out of football and taking college classes online when Washington signed him to the practice squad in December. An injury to Alex Smith and the release of Dwayne Haskins thrust him into action late in the season, and he made his NFL playoff debut in a loss to the eventual Super Bowl-champion Buccaneers.

The year-old impressed against Tampa, going 26 of 44 for yards, a touchdown pass and an interception and rushing for a team-high 46 yards and a score. I want to be in the NFL. I want to keep playing ball. Washington could also trade for or sign a veteran to compete with Heinicke and Allen or use the No.

Then you look at the quarterbacks that are out there. He made his first start with the Panthers that year and didn't play again until relieving Haskins in Week 16 this season. His familiarity with offensive co-ordinator Scott Turner's system gave the coaching staff confidence that Heinicke could play in the wild-card game with Smith nursing a right calf injury.

Heinicke separated his left shoulder against Tampa Bay diving for the pylon at the corner of the end zone and in the process earned respect from teammates for his gutsy play. With the backing of two major NHL markets, the trajectory of professional women's hockey looks to be going up. Hefford, 43 of Trenton, Ont.

Both she and ex-teammate Hayley Wickenheiser, among others, have spoken out in recent months about the need for a women's hockey partner in the NHL. In partnering with the Rangers and Maple Leafs, Hefford hopes to take advantage of existing infrastructure and resources — in addition to the teams' investments — to grow the PWHPA into a singular women's hockey league that can become the foundation of the sport.

So they're growing up in a world that's different than it was 20 or 30 years ago," Hefford said. The world championships and Four Nations Cup were both cancelled, the latter for the second straight year following a dispute between Swedish players and their national organization. But the momentum of women's hockey is starting to mount here and its starting to get back to a place where we were pre-COVID," Hefford said. Like last season, the Lakers are the big story in the NBA.

The parade will be held on the Hillsborough River near downtown Tampa. Mayor Jane Castor is again emphasizing that people attending the parade must wear masks outdoors and observe social distancing rules. After Tampa Bay's win over the Kansas City Chiefs in Sunday's title game, throngs of people gathered in the city's entertainment districts. Many were seen maskless despite the ordinances requiring them.

Brian Ford, chief operating officer of the Buccaneers, said in video announcement that fans should heed the rules as they celebrate the team's victory. The Associated Press. On the streets of Schio, a manufacturing town on the Leogra River in northern Italy, Canadian basketball star Natalie Achonwa is arguably as famous as she is in any major city in her homeland.

The six-year WNBA veteran and fixture with the women's national team is on a professional contract with Schio during the WNBA offseason, and fans can easily pick her out of a crowd. The team is supported by the Famila supermarket chain and draws major talent from around the world, including WNBA players looking to supplement their salaries with often-lucrative overseas contracts.

U Sports players can sign offseason development contracts with the CEBL without sacrificing their college eligibility, and the league has been a magnet for former players wanting to play close to home.

The ACSS consists of 18 questions in four subscales: 1 typical symptoms2 differential diagnosis, 3 quality of life, and 4 additional circumstances.

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Siniakova vs lim betting expert Yahoo Sports. All participants answered two questionnaires: Innate lymphoid cells t betting Tract Discomfort VTD scale and the Modern Singing Handicap Index MSHI that investigates the vocal siniakova vs lim betting expert perceived by singers, siniakova vs lim betting expert the results of both instruments p symptomsthe higher the vocal handicap for singing. Items were generated for the instruments to assess biologic activity based on physician input. Respondents indicated whether they received an IC diagnosis and how long ago, whether they tried CAM, and who recommended it. From afar, it looked like an injury. Using a urethral device at the fossa navicularis, bladder pressure during voiding can be estimated by a minimal invasive technique. Participants were split into two groups based on extreme elevations on RC1; the high RC1 group produced higher scores on 39 scales including clinically significant elevations on 17 scales.
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Cheong worried that if the condominium management doesn't allow residents who have tested positive to enter, these patients will not be able to quarantine at home. Agora Society of Malaysia policy researcher Lim Chee Han, a health economics and public health specialist, agreed that such measures contradict the Health Ministry's home quarantine requirement.

He said the ministry is getting overwhelmed because of the spike of confirmed cases, resulting in a slow down of Covid tests conducted and the admission of those positive into hospitals. As a result, an infected person would not be sent to a hospital immediately. On the other hand, Lim warned that if someone uninfected goes to high-risk places such as hospitals or clinics to get tested, their risk of contracting the virus will increase. He further explained that a medical paper issued last May found that a Covid patient's symptoms will improve on the fifth day upon symptoms onset; after the 10th day, their symptoms will be gone and they will lose the ability to infect others.

For those who are asymptomatic, they are considered as recovered patients 10 days after the date of their first positive test. According to Lim, because of the lack of resources, it may take up to seven days for the Health Ministry to take a Covid patient to a hospital.

Under the ministry's guidelines, a patient can be discharged after 10 days as they are no longer infectious. Therefore, Lim pointed out that swab tests are not necessary steps unless the patients have very serious symptoms, or do not have suitable conditions for home quarantine.

Malaysiakini previously reported that several condominiums' management made it mandatory for their tenants to get a Covid test. Some of the condominiums required foreign workers living in the building to submit their Covid test results to the management; otherwise, they would be barred from entering the premises.

Migrant rights group Our Journey director Sumitha Shaanthinni Krishna described the ruling as discriminatory and argued that the management does not have the power to bar residents from entering. Offering wall-sized pictures, the latest home video projectors bring genuine cinema thrills home. Get these top picks while you still can. Instead, she is fighting for her life in a hospital in the capital Naypyitaw after she was shot in the head when police cracked down on a protest against the military coup.

Myanmar's army seized power on Feb. Mya Thwate Thwate Khaing, a year-old grocery store worker, had traveled with her sisters from a nearby village to Naypyitaw, the army-built capital in the center of the country, for a protest on Tuesday. Frank Grillo has an insatiable appetite for flexing his movie muscles. Israel has become the world's guinea pig, providing the largest case study of whether vaccines really could be the light at the end of the tunnel.

Its rapid and world-leading rollout of the Pfizer shot has provided new and crucial data, offering insights into how how effective vaccines are and if they could gain the upper hand in the pandemic. Results are trickling in, and they are promising. He says the first groups to be inoculated are seeing a dramatic drop in illnesses. Every detail was digitally tracked, down to in which arm the patient was jabbed and what vial it came from.

The big question of course is whether vaccines can end the pandemic altogether. Crucially, there may be early signs that vaccines tamper transmission, as well as illness. But Professor Michal Linial, from the Hebrew University, predicts it will become endemic and seasonal. But it will never stay with us the situation that we are now. It will become a very, you know, like The Milan monastery housing Leonardo da Vinci's "The Last Supper" has reopened its doors, bringing delight and solace to locals who for once can visit the masterpiece without booking weeks ahead.

The 36 pages outlining the proposed laws were given to mobile operators and telecoms license holders for comment on Tuesday - just over a week after the army overthrew the elected government of Aun San Suu Kyi, a statement from the groups said. Reuters was not able to independently verify the document, dated Feb. When Walt Disney Co.

The media giant will in weeks to come hold three different meetings with advertisers to describe new marketing opportunities across its portfolio of assets. It is an important matchup for both players, as each looks to critical win to advance to the next round and improve their rankings. The following is a free expert sports astrology betting horoscope breakdown for both Tennis players based on birthday information. The horoscope breakdown looks at astrology chart, Vedic and western for the day of the match.

The expert analytics betting outcomes are based on Tennis News and Tennis Rankings. Based on the astrology chart for both players on the day of the Wuhan Open match, our highly successful power ranking and predictive sports betting algorithm suggests the following result highest power ranking index wins :.

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